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Hydromorphone belongs to the family of medications known as opioid analgesics (narcotic pain relievers). It is used to treat moderate-to-severe pain, including pain after surgery. Hydromorphone works on the brain to increase the ability to tolerate pain. Hydromorphone begins to work within 30 minutes for oral (by mouth) forms.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
How should I use this medication?
The usual adult starting dose of hydromorphone taken by mouth is 2 mg to 4 mg every 4 to 6 hours as required. Rectal suppositories are often used at night, with the usual dose of 1 suppository every 6 to 8 hours.
Swallow the tablets whole with fluids. Cutting, breaking, chewing, crushing, or dissolving hydromorphone tablets can result in dangerous adverse events, including death.
Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons. The oral liquid may be diluted in fruit juice or other beverage if desired.
Are there any other precautions or warnings for this medication?
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Alcohol use: Alcohol increases the risk of severe side effects of hydromorphone, such as decreased blood pressure, seizures, breathing problems, and severe drowsiness. Consuming alcohol while you are taking hydromorphone is not recommended.
Abdominal (stomach) conditions: Like other narcotic medications, hydromorphone may make the diagnosis of abdominal conditions more difficult or it may worsen these conditions. If you have a history of abdominal problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Accidental use: Accidental ingestion or use of as little as one dose of hydromorphone by someone for whom it has not been prescribed can lead to a fatal overdose. Children are especially at risk. Keep this medication out of sight and reach of children.
Constipation: Constipation happens frequently while taking opioid (narcotic) pain relievers on a regular basis. Ask your doctor or pharmacist for advice on how to manage constipation.
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